Rare Disease · Prior Authorization Intelligence · Live June 2026

Stop guessing.
Get approved.

Select your drug, payer, and state. PathToApproval walks your office through every step — from benefits investigation through post-approval monitoring. Built for rare disease. Built for your office.

→ Request Early Access See how it works
9 Drug Modules — Live Now
ATTR Amyloidosis
eplontersen (Wainua)
AstraZeneca · hATTR-PN
vutrisiran (Amvuttra)
Alnylam · hATTR-PN + ATTR-CM
acoramidis (Attruby)
BridgeBio Pharma · ATTR-CM
Hereditary Angioedema (HAE)
lanadelumab (Takhzyro)
Takeda · HAE Prophylaxis
berotralstat (Orladeyo)
BioCryst · HAE Prophylaxis
garadacimab (Andembry)
CSL Behring · HAE Prophylaxis
donidalorsen (Dawnzera)
Ionis · HAE Prophylaxis
sebetralstat (Ekterly)
KalVista · HAE Acute Treatment
C1-INH SC (Haegarda)
CSL Behring · HAE Prophylaxis
49
States Live
9
Drug Modules
14
Workflow Tabs
2
Disease Areas
Platform Features
Everything your office needs before a PA is submitted.
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Patient Intake & Readiness Score
Enter clinical data only — no patient identifiers. PathToApproval scores readiness, identifies blockers, and generates a personalized action plan before you submit a single form.
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Benefits Investigation Playbook
Select the patient's plan and get the exact call script, submission route, and red flags for that specific payer. No guessing which number to call or what to ask.
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PA Criteria — Drug & Payer Specific
Step therapy requirements, required documentation, HCPCS codes, and payer-specific clinical criteria for every drug and payer combination. Updated continuously.
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Denial Pathway Intelligence
A complete five-step escalation ladder from step therapy override through external independent review — including the state law protections most offices never know exist.
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AI-Personalized Appeal Letters
Five document types drafted by AI based on the patient's specific profile — medical necessity, peer-to-peer prep memos, step therapy override letters, and more.
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Reauthorization Workflow
Month-by-month timeline, required documentation checklist, and baseline tracking guide to protect against therapy gaps at the 12-month renewal.
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Affordability & Patient Support
Every savings program, independent foundation, and patient support resource — with eligibility criteria and enrollment contacts in one place.
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Specialty Pharmacy & Coding
Authorized specialty pharmacies, hub enrollment contacts, HCPCS billing codes, and J-code accuracy guidance for every drug module.
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HIPAA-Safe by Design
No patient identifiers are ever entered or stored. Clinical data only. Stateless sessions cleared on close. No BAA required from your office.
Who It's For
Built for rare disease office staff.

Prior authorization for rare disease therapeutics is uniquely complex — multiple payer types, evolving step therapy criteria, high denial rates, and devastating consequences for patients when therapy is delayed. PathToApproval was built to give every physician office the knowledge, tools, and confidence to fight those denials and win.

Neurology, cardiology, and allergy/immunology rare disease offices
Prior authorization coordinators and office managers
Practices managing hATTR-PN, ATTR-CM, and Hereditary Angioedema (HAE)
Offices working across multiple payers, multiple states, and multiple disease areas simultaneously
National Coverage
49 states. Every major payer.

Coverage includes state-specific step therapy laws, BCBS affiliates, Medicare MAC jurisdictions, and state Medicaid programs for all 49 live states.

Core Payers — All 49 States
Aetna Commercial
UnitedHealthcare
BCBS (State Affiliate)
Cigna Commercial
Humana Commercial
Medicare Part B
State Medicaid
Live States
CT
NY
MA
NJ
PA
MD
VA
NC
SC
GA
FL
TN
KY
WV
DE
DC
ME
VT
NH
RI
AL
TX
CA
OH
IL
MI
WA
CO
MN
AZ
OR
MO
WI
IN
LA
NV
UT
AR
IA
KS
MS
NE
OK
ID
MT
ND
SD
WY
NM
Now Accepting Beta Access Requests

Ready to put PathToApproval in your office?

We are currently onboarding select rare disease physician offices for early access. Reach out to request access for your practice.

→ Request Access — contact@pathtoapproval.com